| Issue |
Photoniques
Number 134, 2025
Optics for Life Sciences
|
|
|---|---|---|
| Page(s) | 30 - 35 | |
| Section | Focus: optics for life sciences | |
| DOI | https://doi.org/10.1051/photon/202513430 | |
| Published online | 28 November 2025 | |
Photonic pathways toward real-time tissue assessment
LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands
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Abstract
Photonics is transforming pathology by enabling fast, label-free tissue diagnostics. We developed Higher Harmonic Generation Microscopy (HHGM), a compact femtosecond-laser platform combining SHG, THG, and autofluorescence to image unprocessed tissue with submicron resolution. HHGM reproduces histological architecture within minutes, preserves tissue for further analysis, and enables AI-driven, real-time diagnostics across cancer types.
© EDP Sciences, 2025
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