Photonic pathways toward real-time tissue assessment

LaserLab Amsterdam, Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands

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Abstract

Photonics is transforming pathology by enabling fast, label-free tissue diagnostics. We developed Higher Harmonic Generation Microscopy (HHGM), a compact femtosecond-laser platform combining SHG, THG, and autofluorescence to image unprocessed tissue with submicron resolution. HHGM reproduces histological architecture within minutes, preserves tissue for further analysis, and enables AI-driven, real-time diagnostics across cancer types.